2025

Köhnen, S., Ulbricht, P., Sturm, A., Carcaud, J., Sandoz, J.-C., Eltz, T., Beye, M. The fru gene specifies male cooperative behaviors in honeybee colonies. Nature Communications 16, 11203 (2025). https://doi.org/10.1038/s41467-025-67392-2

2024

Seiler, J., Beye, M. Honeybees' novel complementary sex-determining system: function and origin. Trends in Genetics 40(11), 969–981 (2024). https://doi.org/10.1016/j.tig.2024.08.001

Sommer, V., Seiler, J., Sturm, A., Köhnen, S., Wagner, A., Blut, C., Rössler, W., Goodwinn, S. F., Grünewald, B., Beye, M. Dedicated developmental programing for group-supporting behaviors in eusocial honeybees. Science Advances 10(44), eadp3953 (2024). https://doi.org/10.1126/sciadv.adp3953

2023

Otte, M., Netschitailo, O., Weidtkamp-Peters, S., Seidel, C. A. M., Beye, M. Recognition of polymorphic Csd proteins determines sex in the honeybee. Science Advances 9(40), eadg4239 (2023). https://doi.org/10.1126/sciadv.adg4239

Netschitailo, O., Wang, Y., Wagner, A., Sommer, V., Verhulst, E. C., Beye, M. The function and evolution of a genetic switch controlling sexually dimorphic eye differentiation in honeybees. Nature Communications 14, 463 (2023). https://doi.org/10.1038/s41467-023-36153-4

Carcaud, J., Otte, M., Grünewald, B., Haase, A., Sandoz, J.-C., Beye, M. Multisite imaging of neural activity using a genetically encoded calcium sensor in the honey bee. PLoS Biology 21(1), e3001984 (2023). https://doi.org/10.1371/journal.pbio.3001984

2019

Roth, A., Vleurinck, C., Netschitailo, O., Bauer, V., Otte, M., Kaftanoglu, O., Page Jr., R. E., Beye, M. A genetic switch for worker nutrition-mediated traits in honeybees. PLoS Biology 17(3), e3000171 (2019). https://doi.org/10.1371/journal.pbio.3000171

2014

Schulte, C., Theilenberg, E., Müller-Borg, M., Gempe, T., Beye, M. Highly efficient integration and expression of piggyBac-derived cassettes in the honeybee (Apis mellifera). PNAS 111(24), 9003-9008 (2014). https://doi.org/10.1073/pnas.1402341111

2013

Beye, M., Seelmann, C., Gempe, T., Hasselmann, M., Vekemans, X., Fondrk, M. K., Page Jr., R. E. Gradual molecular evolution of a sex determination switch through incomplete penetrance of femaleness. Current Biology 23(24), 2559-2564 (2013) https://doi.org/10.1016/j.cub.2013.10.070

2010

Hasselmann, M., Lechner, S., Schulte, C., Beye, M. Origin of a function by tandem gene duplication limits the evolutionary capability of its sister copy gene. PNAS 107(30), 13378-13383 (2010)  https://doi.org/10.1073/pnas.1005617107

2009

Gempe, T., Hasselmann, M., Schiøtt, M., Hause, G., Otte, M., Beye, M. Sex determination in honeybees: Two separate mechanisms induce and maintain the female pathway. PLoS Biology 7(10), e1000222 (2009). https://doi.org/10.1371/journal.pbio.1000222

2008

Hasselmann, M., Gempe, T., Schiøtt, M., Nunes-Silva, C. G., Otte, M., Beye, M. Evidence for the evolutionary nascence of a novel sex determination pathway in honeybees. Nature 454, 519-522 (2008) https://doi.org/10.1038/nature07052

Hasselmann, M., Vekemans, X., Pflugfelder, J., Koeniger, N., Koeniger, G., Tingek, S., Beye, M. Evidence for convergent nucleotide evolution and high allelic turnover rates at the complementary sex determiner gene of western and asian honeybees. Molecular Biology and Evolution 25(4), 696-708 (2008). https://doi.org/10.1093/molbev/msn011

2006

The Honeybee Genome Consortium. Insights into social insects from the genome of the honeybee Apis mellifera. Nature 443, 931-949 (2006). https://doi.org/10.1038/nature05260

2004

Hasselmann, M., Beye, M. Signatures of selection among sex-determining alleles of the honey bee. PNAS 101(14), 4888-4893 (2004). https://doi.org/10.1073/pnas.0307147101

2003

Beye, M., Hasselmann, M., Fondrk, M.K., Page Jr., R. E., Omholt, S. W. The gene csd is the primary signal for sexual development in the honeybee and encodes a SR-type protein. Cell 114(4), 419-429 (2003). https://doi.org/10.1016/S0092-8674(03)00606-8